APPSeCONNECT provides seamless integration between Magento and SAP irrespective of their hosting server locations. The platform is fully capable of integrating and connecting systems which are hosted on different servers in different countries. There will be no issues in terms of integration. However, Data Sync has a proportional dependency on the connection speed between the two hosted servers.
Learn more about SAP Magento Integration at https://www.appseconnect.com/sap-business-one-and-magento-integration/